NAD+ precursors: NMN vs nicotinamide riboside, what the trials show

Why NAD+ matters

NAD+ is a coenzyme central to mitochondrial energy production and DNA repair. Levels decline ~50% between ages 40 and 60, and restoring them is a primary target of longevity research.

NMN vs NR head-to-head

Both precursors have shown 40–60% increases in whole-blood NAD+ at doses of 500–1,000 mg/day. NR has the longer safety track record; NMN has the more recent positive functional trials in older adults.

Citations available on request. ZYVORA articles reference peer-reviewed clinical research published in journals including JAMA, The Lancet, Nutrients, and the American Journal of Clinical Nutrition.